911±¬ÁÏÍø

Michael Oelschlägel

Research Group Microbiology/Biohydrometallurgy

Dr. Michel Oelschlägel

Post Doc
Clemens-Winkler-Bau, room 150

+49 3731 39-2103
michel [dot] oelschlaegel [at] bio [dot] tu-freiberg [dot] de

Das Foto zeigt einen Bioreaktor mit Flüssigkeit im Labor
911±¬ÁÏÍøBAF

Research interests

  • Sphingopyxis fribergensis - Strain and proteins
  • Enzyme cascades for biotechnological application
  • Gene syntheses and gene modifications
  • Recombinant protein expression and optimization
  • Gene-Knock-Outs
  • Establishment of industrial processes based on biotechnology
  • Fine chemicals, pharmaceuticals, flavours, fragrances...
  • Patents
  • Business founding
  • Actinobacteria, mainly rhodococci (enrichment and degradation of aromatic compounds)
  • Membrane-bound proteins
  • Characterization of styrene oxide isomerases
  • Protein biochemistry and bioanalytics
  • Biotransformation and biotechnology

List of publications

Publikationsliste Michel Oelschlägel
  • Biotechnological production processes (lecture)
  • Enzymes: purification, characterization, mechanisms (lecture)
  • Source-related control and treatment of mining water in Saxony (funded by Krüger foundation)
    - Investigation of the microbiological community in the mine (metagenomic studies)
    - Establishing a fast assay for the identification of hotspots/ metal-contaminated sites
    - Investigating biotic and abiotic factors for metal release
     
  • Styrene oxides isomerases from soil bacteria for biotechnological application (funded by DBU)
    - Investigation of styrene degradation in soil bacteria
    - Isolation of novel styrene-degrading microorganisms (description of the novel species Sphingopyxis fribergensis)
    - Recombinant membrane protein expression
    - Establishing biotechnological processes for the syntheses of phenylacetaldehydes and phenylacetic acids
    - Usage of co-metabolic pathways for synthesis
     
  • Biotechnological synthesis of aromatic carboxylic acids or aromatic alcohols from natural resources (funded by DBU)
    - Usage of natural or recombinant enzyme cascades for biosyntheses
    - Gene syntheses and gene modifications, promoter construction
    - Whole-cell biocatalysis
    - Establishment of bioprocesses for industrial applications (E. coli, Pseudomonas fluorescens, ...)
    - Gene-Knock-Outs in pseudomonads and E. coli
    - Optimization of co-metabolic processes
    - Fermenter-based cultivation and transformation
     
  • Production of antioxidants for industrial applications (funded by Krüger foundation)
    - Establishing industrial processes for antioxidant production
    - Up-scaling and downstream-development
    - Establishing an economic strategy for an industrial application of the processes and products (business plan)
    - Genetic optimization of biocatalysts by constructing expression cassettes and genes
     
  • Production of caffeic acid for the synthesis of a novel and sustainable antioxidant (funded by SMWA, EFRE and Krüger foundation)
    - Screening for plants with important target compounds + investigating level of useful ingredients during vegetation period to estimate harvest time
    - Organization of open-field and glashouse cultivation with partners using selected plants
    - Establishing methods to isolate + enzymatically transform plant ingredients into caffeic acid and to purify the acid obtained
    - Up-scaling process and purification, e.g. by preparative HPLC
    - Using the self-produced "green" caffeic acid as a basis for antioxidant synthesis + establishing a complete and up-scaled process
    - Carrying out market analyzes and surveys to estimate the economic potential of the process
    - Economic analysis of the entire process including cost-analysis
2011-2014 Ph.D scholarship from the Deutsche Bundesstiftung Umwelt (DBU)
2015 Ph.D award "Bernhard von Cotta Preis" of the "Verein der Freunde und Förderer der 911±¬ÁÏÍø Bergakademie Freiberg e.V."
2016 Award for the best theses on the topic "resource efficiency" (in Saxony) awarded by the "Dresdner Gesprächskreis der Wirtschaft und der Wissenschaft e.V."
  • Student research project (2009): Identifikation des Styrolabbaus in Rhodococcus opacus 1CP. - Identification of the styrene metabolism in Rhodococcus opacus 1CP.
  • Diploma project (2010): Anreicherung und biochemische Charakterisierung der Styroloxid-Isomerase aus Rhodococcus opacus 1CP. - Enrichment and biochemical characterization of the styrene oxide isomerase from Rhodococcus opacus 1CP.
  • Dissertation (2015): Identification of bacterial styrene oxide isomerases and evaluation of their applicability for the environment-friendly synthesis of phenylacetaldehydes.
Study and Professional background
since 2021Scientist at Environmental Microbiology Group, 911±¬ÁÏÍøBAF, Validation-Project, funded by SMWA, EFRE and Krüger foundation (head of the project)
2019-2020Scientist at Environmental Microbiology Group, 911±¬ÁÏÍøBAF, Krüger-Project (head of the project)
since 2018Lecturer at the 911±¬ÁÏÍøBAF
2015-2017Scientist at Environmental Microbiology Group, 911±¬ÁÏÍøBAF, DBU-Project (head of the project)
2015Graduation: Dr. rer. nat., 911±¬ÁÏÍøBAF
2011-2015Ph.D.: at Environmental Microbiology Group, 911±¬ÁÏÍøBAF, DBU-Scholarship
2010Graduation: Dipl.-Nat., 911±¬ÁÏÍøBAF
2008Study: Environmental Microbiology / Biotechnology, 911±¬ÁÏÍøBAF
2005-2010Study: Applied Natural Science, 911±¬ÁÏÍø Bergakademie Freiberg (911±¬ÁÏÍøBAF)